Professor Paul Little | University of Southampton

Stephanie Hughes, Tamar Pincus, Adam W. A. Geraghty, Carolyn A. Chew-Graham, Beth Stuart, Paul Little, Michael Moore & Hollie Birkinshaw, 2026, British Journal of Pain, 20(5), 292-309

DOI: 10.1177/20494637261464804

Type: article

A digital intervention to protect cognitive health in older adults with cognitive impairment: a three-arm, open-label, randomised controlled trial

Paul Little, Rosie Essery, Jane Somerville, Taeko Becque, Victoria Hayter, Beth Stuart, Katherine Bradbury, Gareth Griffiths, Simon J. Griffin, Tony Kendrick, Nanette Mutrie, Sian Robinson, Louise Robinson, Guiqing Lily Yao, Shihua Zhu, Sebastien Pollet, James Denison-Day, Helen Brooker, Anne Corbett, Paul Lee, Shanaya Rathod, Bernard Gudgin, Rosemary Phillips, Tom Stokes, John Niven, Angela McCullagh, Sara Mccloskey, Martin N. Rossor, John Gallacher, John O'Brien, Clive Ballard & Lucy Yardley, 2026, The Lancet Primary Care, 2(8)

DOI: 10.1016/j.lanprc.2026.100192

Type: article

System pressures may threaten patient perceptions and experiences of empathy in primary care consultations: A nested qualitative interview study

Rachel Dewar-Haggart, Emma Teasdale, Sebastien Pollet, Geraldine M. Leydon, Hazel A Everitt, Leanne Morrison, Helen Atherton, Jeremy Howick, Isla Davis, Shola Falohun, Jennifer Bostock, Jane Vennik, Nadia Cross, Paul Little, Christian D. Mallen, Matthew J. Ridd, Amy Herbert, Michelle E. Robinson, Jacqueline Nuttall, Taeko Becque, Kirsty Garfield, Beth Stuart, Nazrul Islam, Paul H. Lee & Felicity L. Bishop, 2026

DOI: 10.64898/2026.08.24.26361185

Type: other

Mixed (reusable/single-use) catheter management versus single-use catheter management for intermittent catheter users (MultICath): a non-inferiority randomised controlled trial

Mandy Fader, Margaret Macaulay, Nina Wilson, Thomas J. Chadwick, Nicola Goudie, Gillian C. Watson, Alaa Abouhajar, Ruth Wood, Tracey Sach, Sara McCloskey, Miriam R. Avery, Jackie Broadbridge, Brian S. Buckley, Bridget Clancy, Alan Cottenden, Sylvia Dickson, Carole Dorling, Karen Guerrero, Suzanne Hagen, Catherine P. James, Rajvinder Khasriya, Paul Little, Alex Lymouri, Carl R. May, Doreen McClurg, Mike Moore, Cathy Murphy, Jacqui Prieto, Isabel Reading, Anthony Timoney & Sandra Wilks, 2026, International Journal of Nursing Studies, 180

DOI: 10.1016/j.ijnurstu.2026.105536

Type: article

Understanding and addressing the obstacles to a trial of face masks in schools: a mixed-methods feasibility study

Ru Jia, Sophie Carlisle, Adam W.A. Geraghty, Sofia Strommer, Kieran Ayling, Jonathan Ball, Kirsty Bolton, Ben Cowling, Lucy Fairclough, Karen Jones, Wei Shen Lim, Paul Little, Tricia McKeever, Joanne Morling, Simon Royal, Paddy Tighe, Katherine Bradbury & Kavita Vedhara, 2026, Pilot and Feasibility Studies, 12(1)

DOI: 10.1186/s40814-026-01825-7

Type: article

Nirmatrelvir–ritonavir versus usual care in at-risk adults with early SARS-CoV-2 infection in the UK, 2022–23: virological and immunological results of an open-label randomised trial (PANORAMIC)

David M. Lowe, Shengyuan Zhang, Samuel Ellis, Laura Buggiotti, Charles Miller, Victoria Harris, Adrian M. Shields, Alex G. Richter, Elen Ashmore, Ly Mee Yu, Saye Khoo, F. D.Richard Hobbs, Paul Little, Christopher C. Butler, Judith Breuer, Joseph F. Standing, Haroon Ahmed, Monique Andersson, Clare Bateman, Nicholas S. Berry, Daniel Butler, Lucy Cureton, Jennifer C. Davies, Michelle A. Detry, Melissa Dobson, Jienchi Dorward, May Ee Png, Philip Evans, Mark Fitzgerald, Nick Francis, Oghenekome A. Gbinigie, Nigel D. Hart, Gail Hayward, Jane Holmes, Bhautesh D. Jani, Mark Lown, Kerenza Hood, Joe Marion, Micheal McKenna, Sam Mort, Jonathan S. Nguyen-Van-Tam, Mahendra G. Patel, Meena Patil, Stavros Petrou, Najib M. Rahman, Duncan B. Richards, Christina T. Saunders, Benjamin R. Saville, Andrew Carson-Stevens & Nicholas P.B. Thomas, 2026, The Lancet Microbe, 7(5)

DOI: 10.1016/j.lanmic.2026.101360

Type: article

Oral nirmatrelvir–ritonavir for Covid-19 in higher-risk outpatients

Christopher C. Butler, Andrew D. Pinto, Victoria Harris, Paul Little, Jane Holmes, Najib M. Rahman, Lucy Cureton, Gail Hayward, Duncan B. Richards, David M. Lowe, Joseph F. Standing, Judith Breuer, Kerenza Hood, May Ee Png, Stavros Petrou, Jienchi Dorward, Mahendra G. Patel, Nicholas P.B. Thomas, Philip Evans, Nigel D. Hart, Bhautesh D. Jani, Banafshe Hosseini, Srinivas Murthy, Kerry McBrien, Amanda Condon, Emily G. McDonald, Peter Daley, Michelle Greiver, Bruno R. da Costa, Peter Selby, Peter Jüni, Todd C. Lee, Haolun Shi, Michelle A. Detry, Christina T. Saunders, Mark Fitzgerald, Nicholas S. Berry, Benjamin R. Saville, Saye H. Khoo, Jonathan S. Nguyen-Van-Tam, F.D. Richard Hobbs & Ly-Mee Yu, 2026, New England Journal of Medicine, 394(16), 1583-1594

DOI: 10.1056/NEJMoa2502457

Type: article

Differentiating pain-related distress from depression in people with persistent musculoskeletal pain: a mixed methods study

Hollie Birkinshaw, Tamar Pincus, Stephanie Hughes, Beth Stuart, Carolyn A. Chew-Graham, Paul Little, Michael Moore, Noureen Shivji & Adam Geraghty, 2026, Pain, 167(6)

DOI: 10.1097/j.pain.0000000000003926

Type: article

Chronic rhinosinusitis: a qualitative study of patient and clinician experiences of the MACRO randomised controlled trial of surgical versus medical management

Jane Vennik, Clare Lockyer-Stevens (née McDermott), Samantha Williams, Mike Thomas, Jim Boardman, Carl M Philpott, Paul Little, Anne Schilder & Claire Hopkins, 2026, BJGP Open, 16(3), e108999

DOI: 10.1136/bmjopen-2025-108999

Type: article

Digital intervention to support cancer survivors: the CLASP research programme

Paul Little, Katherine Bradbury, Beth Stuart, Jane A. Barnett, Adele S. Krusche, Mary Steele, Elena D. Heber, Stephanie Easton, Kirsten A Smith, Joanna Slodkowska-Barabasz, Liz Payne, Teresa Corbett, Guiqing Yao, Sebastien Pollet, Jazzine Kai Smith, Judith Joseph, Megan Lawrence, Dankmar Böhning, Tara Cheetham-Blake, Diana Eccles, Claire Foster, Adam Geraghty, Geraldine Leydon, Andre Matthias Muller, Richard D Neal, Richard Osborne, Shanaya Rathod, Alison Richardson, Chloe Grimmett, Geoffrey Sharman, Roger Bacon, Lesley Turner, Richard Stephens, Tamsin Burford, Laura Wilde, Karen Middleton, Megan E. Liddiard, Kirsty L. Rogers, James Raftery, Shihua Zhu, Karmpaul Singh, Frances H. Webley, Gareth Griffiths, Trudie Chalder, Clare Wilkinson, Elia Watson & Lucy Yardley, 2026, Programme Grants for Applied Research, 14(4)

DOI: 10.3310/PPLHG1141

Type: article

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Research Biography

Biography

Professor Little was the first GP to be awarded a Wellcome HSR training fellowship in 1993 (for research on health promotion), and the first to be awarded an MRC Clinician Scientist Fellowship in 1998 (for research on common self-limiting illness), and in addition current major areas of research are in enabling behaviour change both for health professionals and also in empowering patients.

Professor Little received recognition in the 2018 Queen’s Birthday Honours with the award of a CBE for services to General Practice Research, in June 2019 he was awarded the RCGP Discovery Prize in recognition of his outstanding research in general practice and in November 2020 Paul was awarded The Maurice Wood Award for Lifetime Contribution to Primary Care Research.

In November 2023 Paul was named the Garrod Medallist of the year by the British Society for Antimicrobial Chemotherapy.

Publications