About
Research Fellow in Bioinformatics/Epigenetics within the Faculty of Medicine at the University of Southampton
Research
Research groups
Research interests
- My current research mainly involves working with DNA methylation data to identify epigenetic marks for periconceptional paternal smoking exposure across generations. This Epigenome Wide Association Study is part of the Rhinessa multicentre population project. My expertise includes integrating multi-omic data such as SNP, transcriptome, methylation and interactome (PPI) at the system level to understand the molecular mechanisms underlying the origins of complex diseases. In my former position, I worked on the epigenetic effects of Maternal Gestation Diabetes (GDM) using the UPBEAT Offspring data supported by Diabetes UK.
Research projects
Publications
21 publications
Page 1 of 3
Faidra Laskou, Leo Westbury, Negusse Kitaba, John W. Holloway, Elaine Dennison & Nicholas Fuggle,
2026, Aging Clinical and Experimental Research
Type: article
Lisa Maier, Yidan Sun, Jaanika Kronberg, Erik Abner, Kayesha Coley, Ingo Marenholz, Stefan Weiss, Ronja Foraita, Tarik Karramass, Juha Mykkänen, Natalia Hernandez-Pacheco, Carol A. Wang, Negusse T. Kitaba, Sonali Pechlivanis, Emmanuelle Bouzigon, Casper E. Tingskov Pedersen, Ann-Marie M. Schoos, John Curtin, Sara Kress, Alba Hernangomez-Laderas, Francesco Foppiano, Sarah Ashley, Chiara Batini, Luke Bryant, Georg Homuth, Christian Gieger, Stefanie Gilles, Leo-Pekka Lyytikäinen, Suvi Rovio, Katja Pahkala, Raphaël Vernet, Rudolph Valenta, Sabrina Llop, Maties Torrent, Andreas Böck, Mimi L.K. Tang, Carsten B. Schmidt-Weber, Andres Metspalu, Tõnu Esko, Aline B. Sprikkelman, Catherine John, Young-Ae Lee, Kirsten Beyer, Henry Völzke, Iris Pigeot, Claudia Traidl-Hoffmann, Liesbeth Duijts, Haojie Lu, Olli T. Raitakari & John W. Holloway,
2026, Journal of Allergy and Clinical Immunology, 158(1), 194-208
Type: article
Nahid Sultana, Fen Yang, Negusse Kitaba, Stephen Potter, John W Holloway, S Hasan Arshad & Hongmei Zhang,
2026, Epigenomes, 10(2)
Type: article
Toril Morkve Ostergaard, Juan Pablo Lopez-Cervantes, Negusse Tadesse Kitaba, Marianne Lonnebotn, Randi J Bertelsen, Simone Accordini, Christer Janson, Shyamali C Dharmage, Karl A Franklin, Francisco Javier Callejas Gonzalez, Mathias Holm, Ane Johannessen, Caroline Lodge, Andrei Malinovschi, Anna Oudin, Francisco Gomez Real, Anders Flataker Viken, Vivi Schlunssen, John W Holloway & Cecilie Svanes,
2026
Type: other
Sandra Casas Recasens, Julieta Viglino, Maaike De Vries, Judith M. Vonk, Xander Bertels, Lies Lahousse, Simon K. Merid, Erik Melén, Negusse Kitaba, John W. Holloway, Maribel Casas, Alvar Agustí & Rosa Faner,
2025, European Respiratory Journal, 66(Suppl. 69)
Type: conference
Negusse Tadesse Kitaba, Lesley Workman, Cheryl Cohen, Diana Baralle, Ellen Kong, Maresa Botha, Marina Johnson, David Goldblatt, Mark P. Nicol, John W. Holloway & Heather J. Zar,
2025
Type: other
Negusse Tadesse Kitaba, Toril Mørkve Østergaard, Marianne Lønnebotn, Simone Accordini, Francisco Gómez Real, Andrei Malinovschi, Anna Oudin, Bryndis Benediktsdottir, Francisco Javier Callejas González, Leopoldo Palacios Gómez, Mathias Holm, Nils Oskar Jõgi, Shyamali C. Dharmage, Svein Magne Skulstad, Vivi Schlünssen, Cecilie Svanes & John W. Holloway,
2025, Communications Biology, 8(1)
Type: article
Maggie P. Fu, Karlie Edwards, Erick I. Navarro-Delgado, Sarah M. Merrill, Negusse T. Kitaba, Chaini Konwar, Piush Mandhane, Elinor Simons, Padmaja Subbarao, Theo J. Moraes, John W. Holloway, Stuart E. Turvey & Michael S. Kobor,
2025
Type: other
Shaobo Li, Natalia Spitz, Akram Ghantous, Negusse Kitaba, Faisal I. Rezwan, S. Hasan Arshad & John W. Holloway,
2024, Communications Biology, 7(1)
Type: article
Negusse Tadesse Kitaba, Gerd Toril Mørkve Knudsen, Ane Johannessen, Faisal I. Rezwan, Andrei Malinovschi, Anna Oudin, Bryndis Benediktsdottir, David Martino, Francisco Javier Callejas González, Leopoldo Palacios Gómez, Mathias Holm, Nils Oskar Jõgi, Shyamali C. Dharmage, Svein Magne Skulstad, Sarah H. Watkins, Matthew Suderman, Francisco Gómez-Real, Vivi Schlünssen, Cecilie Svanes & John W. Holloway,
2023, Clinical Epigenetics, 15(1), 131
Type: article
Biography
Dr Negusse graduated from Addis Ababa University with a BSc in Biological Science and an MSc in Biodiversity. He completed his MSc in Bioinformatics at Cardiff University. He undertook research into gene regulation, pathway analysis and protein structure prediction to support drug discovery at the University of South Wales, graduating with a PhD in Computational Biology in 2015.
Dr Negusse has a keen interest in understanding how genetics and environmental interactions affect gene function and disease outcomes. He joined the University of Southampton, Faculty of Biological Science in 2017 where he investigated the effect of maternal gestational diabetes on the offspring epigenome. His current work in the Faculty of Medicine involves studying the transgenerational effect of paternal smoking.
Qualifications
PhD, Computational Biology, University of South Wales 2015
MSc, Bioinformatics, Cardiff University 2010
MSc, Biodiversity, Addis Ababa University 2006
BSc, Biological Science, Addis Ababa University 1999
Appointments held
Research Fellow in Bioinformatics/ Epigenetics: Rhinessa EWAS Project at Faculty of Medicine, University of Southampton (2020 -present)
Research Fellow in Epigenetics: UPBEAT Diabetes UK project at Faculty of Biological Science, University of Southampton (2017 to 2020)
Bioinformatics Scientist II PhoreMost Ltd, Cambridge (2017)
Prizes
- Fathers’ preconception smoking and offspring DNA methylation (2024)
- Transcriptomic Analysis of SARS-CoV-2 severity in a South African Cohort (2025)