J Holloway: Trangenerational Epigenetic inheritance of allergy in a Multigenerational Cohort

Staff

Lead researchers

Professor John Holloway PhD, FHEA, FERS

Associate Vice-President (Interdisciplinary Research)

Research interests

Human genetics
Epigenetics
Respiratory Disease

Connect with John

Email: J.W.Holloway@soton.ac.uk

Research outputs

Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

Olivia Solomon, Karen Huen, Paul Yousefi, Leanne K. Küpers, Juan R. Gonzalez, Matthew Suderman, Sarah E. Reese, Christian M. Page, Olena Gruzieva, Peter Rzehak, Lu Gao, Kelly M. Bakulski, Alexei Novoloaca, Catherine Allard, Irene Pappa, Maria Llambrich, Marta Vives, Dereje D. Jima, Tuomas Kvist, Andrea A. Baccarelli, Cory White, Faisal I Rezwan, Gemma C. Sharp, Gwen Tindula, Anna Bergström, Veit Grote, John F Dou, Elena Isaevska, Maria C. Magnus, Eva Corpeleijn, Patrice Perron, Vincent W V Jaddoe, Ellen A. Nohr, Lea Maitre, Maria Foraster, Cathrine Hoyo, Siri E. Håberg, Jari Lahti, Dawn L. DeMeo, Hongmei Zhang, Wilfried Karmaus, Inger Kull, Berthold Koletzko, Jason I Feinberg, Luigi Gagliardi, Luigi Bouchard, Cecilia Host Ramlau-Hansen, Henning Tiemeier, Gillian Santorelli, Rachel L. Maguire, Darina Czamara, Augusto A. Litonjua, Jean-Paul Langhendries, Michelle Plusquin, Johanna Lepeule, Elisabeth B. Binder, Elvira Verduci, Terence Dwyer, Angel Carracedo, Natalia Ferre, Brenda Eskenazi, Manolis Kogevinas, Tim S. Nawrot, Monica Cheng Munthe-Kaas, Zdenko Herceg, Caroline L. Relton, Erik Melen, Dariusz Gruszfeld, Carrie Breton, M D Fallin, Akram Ghantous, Wenche Nystad, Barbara Heude, Harold Snieder, Marie-France Hivert, Janine F. Felix, Thorkild I. A. Sørensen, Mariona Bustamante, Susan K. Murphy, Katri Raikkonen, Emily Oken, John Holloway, Syed Arshad, Stephanie London & Nina Holland, 2022, Mutation Research - Reviews in Mutation Research, 789

DOI: 10.1016/j.mrrev.2022.108415

Type: review

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

Josine L Min, Gibran Hemani, Eilis Hannon, Faisal I Rezwan & John Holloway, 2021, Nature Genetics, 53(9), 1311-1321

DOI: 10.1038/s41588-021-00923-x

Type: article

Filaggrin mutations increase allergic airway disease in childhood and adolescence through interactions with eczema and aeroallergen sensitization

Adrian Chan, William Terry, Hongmei Zhang, Wilfried Karmaus, Susan Ewart, John W Holloway, Graham Roberts, Ramesh Kurukulaaratchy & Syed Hasan Arshad, 2018, Clinical & Experimental Allergy, 48(2), 147-155

DOI: 10.1111/cea.13077

Type: article

Expression of the filaggrin gene in umbilical cord blood predicts eczema risk in infancy

Ali H Ziyab, Susan Ewart, Gabrielle A Lockett, Hongmei Zhang, Syed Arshad, John W Holloway & Wilfried Karmaus, 2017, Clinical & Experimental Allergy, 47(9), 1185-1192

DOI: 10.1111/cea.12956

Type: article

The role of DNA methylation in type 2 diabetes aetiology – using genotype as a causal anchor

Hannah Elliot, Hashem Shihab, Gabrielle A. Lockett, John Holloway, Allan F. McRae, George Davey-Smith, Susan M. Ring, Tom R. Gaunt & Caroline L. Relton, 2017, Diabetes, 66(6), 1713-1722

DOI: 10.2337/db16-0874

Type: article

Multi-generational cohorts in asthma and allergy

Hasan Arshad, Wilfried Karmaus, Hongmei Zhang & John W. Holloway, 2017, Journal of Allergy and Clinical Immunology, 139(2), 415-421

DOI: 10.1016/j.jaci.2016.12.002

Type: article

Tetanus vaccination is associated with differential DNA-methylation: Reduces the risk of asthma in adolescence

Vimala Devi Janjanam, Nandini Mukherjee, Gabrielle A. Lockett, Faisal I. Rezwan, Ramesh Kurukulaaratchy, Frances Mitchell, Hongmei Zhang, Hasan Arshad, John Holloway & Wilfried Karmaus, 2016, Vaccine, 34(51), 6493-6501

DOI: 10.1016/j.vaccine.2016.10.068

Type: article