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This module will deliver a comprehensive analysis of selected topics associated with the cellular and molecular mechanisms that drive cancer development and lead to tumour progression. This will involve exploring the genetic drivers of disease, the mechanisms of aneuploidy, how metabolism is altered, the impact of disrupted cellular signalling pathways on cancer progression, and the mechanisms of tumour metastasis and invasion. In addition, genomic and proteomic research methods utilised to probe the underlying mechanisms of cancer will be discussed.

This module will deliver a comprehensive analysis of selected topics associated with the cellular and molecular mechanisms that drive cancer development and lead to tumour progression. This will involve exploring the genetic drivers of disease, the mechanisms of aneuploidy, how metabolism is altered, the impact of disrupted cellular signalling pathways on cancer progression, and the mechanisms of tumour metastasis and invasion. In addition, genomic and proteomic research methods utilised to probe the underlying mechanisms of cancer will be discussed.

This module will deliver a comprehensive analysis of selected topics associated with the cellular and molecular mechanisms that drive cancer development and lead to tumour progression. This will involve exploring the genetic drivers of disease, the mechanisms of aneuploidy, how metabolism is altered, the impact of disrupted cellular signalling pathways on cancer progression, and the mechanisms of tumour metastasis and invasion. In addition, genomic and proteomic research methods utilised to probe the underlying mechanisms of cancer will be discussed.

This module will deliver a comprehensive analysis of selected topics associated with the cellular and molecular mechanisms that drive cancer development and lead to tumour progression. This will involve exploring the genetic drivers of disease, the mechanisms of aneuploidy, how the immune system influences tumour development, the impact of disrupted cellular signalling pathways on cancer progression, and the mechanisms of tumour metastasis and invasion. In addition, genomic and proteomic research methods utilised to probe the underlying mechanisms of cancer will be discussed.

This module will deliver a comprehensive analysis of selected topics associated with the cellular and molecular mechanisms that drive cancer development and lead to tumour progression. This will involve exploring the genetic drivers of disease, the mechanisms of aneuploidy, how the immune system influences tumour development, the impact of disrupted cellular signalling pathways on cancer progression, and the mechanisms of tumour metastasis and invasion. In addition, genomic and proteomic research methods utilised to probe the underlying mechanisms of cancer will be discussed.

This module will provide a comprehensive understanding of the fundamental principles of genomics and the high throughput technologies used in cancer genomics research. We will explore the structure and organisation of the human genome, the concepts of germline and somatic variants, coding and non coding variants and their effect on the cancer cell, regulation of gene expression and epigenetic modifications in cancer. Students gain practical experience of basic bioinformatics data analysis and interpretation preparing them for careers in cancer genomics. Students are not expected to have prior bioinformatics or computational biology expertise prior to this module.

This module will provide a comprehensive understanding of the fundamental principles of genomics and the high throughput technologies used in cancer genomics research. We will explore the structure and organisation of the human genome, the concepts of germline and somatic variants, coding and non coding variants and their effect on the cancer cell, regulation of gene expression and epigenetic modifications in cancer. Students gain practical experience of basic bioinformatics data analysis and interpretation preparing them for careers in cancer genomics. Students are not expected to have prior bioinformatics or computational biology expertise prior to this module.

This module consists of 9 x 2-hour sessions covering 5 topics.

Click on the timetable link for timetables and details of topics covered. Prior to each topic, the relevant journal and supporting documentation will be uploaded onto the course materials section of the blackboard.

Each topic will be taught by an academic with a specialist interest in the subject area. The first session will consist of a seminar. The content of the seminar will then be discussed by the group, including the lecturer, in order to clarify any points and to frame any questions arising from the lecture that the students find interesting.

A journal paper that extends or applies the knowledge in the seminar, will then be shared with the students. Students should read the methods section immediately, in order to ensure that they are familiar with the basic principles of the techniques and/or any confusing abbreviations used. Methodological queries will be discussed at the session.

The paper and background questions arising from the paper or the seminar will form the basis of the work in the following session (except for topic 5).

For topic 1, students will submit a written critical review of the paper stating the hypothesis and summarising the background, results and conclusion with comments on strengths, weaknesses and any new questions arising as a consequence of the paper. This will be a formative assessment and the critical analysis of the paper and feedback on the written reviews will be discussed during the session 2 of topic 1.

For topics 2, 3 and 4, one or several students will make an oral presentation of the paper, and all the students will be expected to join in a discussion of the paper during and after the presentation. All students will be expected to research other articles to bring to the general discussion of the selected paper. The student(s) who give the presentation will not be assessed on their contribution to the discussion. All students will be given marks for either their oral presentation or discussion contribution for these 3 topics.

For topic 5, all the students will write a critical review of the paper stating the hypothesis and summarising the background, results and conclusion with comments on strengths, weaknesses and any new questions arising as a consequence of the paper. This will be a summative assessment. There will be no session 2/oral presentation for this topic.

Although there is no specific pre-requisite for this module, this is a level 7 module, and an undergraduate level knowledge of immunology is expected.

This module consists of 9 x 2-hour sessions covering 5 topics.

Click on the timetable link for timetables and details of topics covered. Prior to each topic, the relevant journal and supporting documentation will be uploaded onto the course materials section of the blackboard.

Each topic will be taught by an academic with a specialist interest in the subject area. The first session will consist of a seminar. The content of the seminar will then be discussed by the group, including the lecturer, in order to clarify any points and to frame any questions arising from the lecture that the students find interesting.

A journal paper that extends or applies the knowledge in the seminar, will then be shared with the students. Students should read the methods section immediately, in order to ensure that they are familiar with the basic principles of the techniques and/or any confusing abbreviations used. Methodological queries will be discussed at the session.

The paper and background questions arising from the paper or the seminar will form the basis of the work in the following session (except for topic 5).

For topic 1, students will submit a written critical review of the paper stating the hypothesis and summarising the background, results and conclusion with comments on strengths, weaknesses and any new questions arising as a consequence of the paper. This will be a formative assessment and the critical analysis of the paper and feedback on the written reviews will be discussed during the session 2 of topic 1.

For topics 2, 3 and 4, one or several students will make an oral presentation of the paper, and all the students will be expected to join in a discussion of the paper during and after the presentation. All students will be expected to research other articles to bring to the general discussion of the selected paper. The student(s) who give the presentation will not be assessed on their contribution to the discussion. All students will be given marks for either their oral presentation or discussion contribution for these 3 topics.

For topic 5, all the students will write a critical review of the paper stating the hypothesis and summarising the background, results and conclusion with comments on strengths, weaknesses and any new questions arising as a consequence of the paper. This will be a summative assessment. There will be no session 2/oral presentation for this topic.

Although there is no specific pre-requisite for this module, this is a level 7 module, and an undergraduate level knowledge of immunology is expected.

This module is designed to build upon knowledge gained from BIOL6038 Immunology module in Semester 1, providing an in-depth overview of the role of the immune system in cancer and targets for immunotherapeutic strategies. This module is taught by world leading experts in the field of Cancer Immunology and the content of the module is informed by current ongoing research and clinical trials being carried out Southampton.